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  • Status Geschlossen
  • Budget ₹37500 - ₹75000 INR
  • Anzahl der Angebote 1

Projektbeschreibung

By profession, I am a computational chemist. I design the projects from in the field of computational biohysics, where I tried to understand the molecular mechanism of proteins-drug interaction, proteins-membrane interaction. I prepare and present the novel findings of research activities, draft and submit them to peer-reviewed journals.

My current research focus is on Alzheimer’s disease. Alzheimer’s disease (AD), which is the most common form of dementia, accounting for up to 60−80% of all dementia cases. AD is caused by misfolding and aggregation of amyloid βeta (Aβ) peptide, into amyloid-β-fibrils (Aβ fibrils) and affects the structure and function of neural cells leading to synaptic dysfunction It has been reported that cytotoxicity of Aβ fibrils depends on its morphology and remodeling of Aβ fibrils can significantly reduce its cytotoxicity. Understanding the mechanism of amyloid genesis and disruption allows us to design more effective drugs for controlling the disease. In my research work, I am trying to understand Amyloid interaction with probable drug molecules and try to elucidate the mechanism of Amyloid inhibition using molecular dynamics simulations.

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