
Closed
Posted
Paid on delivery
I am about to launch an entirely in-silico study on host–virus interactions and I’m still at the initial hypothesis-formulation stage. My goal is to move from a promising idea to publication-quality results that can support one or more scientific manuscripts. Here is what I need from you: • Shape a clear, testable hypothesis around host–virus interactions, grounded in current literature and biologically meaningful. • Mine and curate public transcriptomic datasets from GEO or ArrayExpress, standardise them, and build a harmonised expression matrix. R/Bioconductor or Python workflows are both fine, as long as the code is reproducible. • Perform differential expression analysis followed by a robust meta-analysis across studies to highlight consistent host signatures. • Translate the strongest signals into molecular-docking experiments that probe host and viral protein interactions; AutoDock Vina, PyMOL and similar tools are welcome if they suit your pipeline. • Deliver a concise results package that already looks and feels like manuscript figures and methods: cleaned data, scripts, statistical outputs, high-resolution plots, docking files and a short narrative of the findings. Acceptance will be based on: 1. A documented analysis pipeline that runs end-to-end on the provided datasets. 2. At least one prioritized hypothesis supported by statistically significant meta-analysis results (adjusted p-values, effect sizes, forest plots). 3. Docking scores and visualisations that clearly link back to the transcriptomic hits. 4. Figures and tables formatted for direct insertion into a journal submission. If you thrive on turning big public data into publishable biological insight, I’d love to see how you would approach this project and how soon we can move to drafting the manuscript.
Project ID: 40593427
49 proposals
Remote project
Active 1 hour ago
Set your budget and timeframe
Get paid for your work
Outline your proposal
It's free to sign up and bid on jobs
49 freelancers are bidding on average $205 USD for this job

Hello, I trust you're doing well. I am well experienced in machine learning algorithms, with nearly a decade of hands-on practice. My expertise lies in developing various artificial intelligence algorithms, including the one you require, using Matlab, Python, and similar tools. I hold a doctorate from Tohoku University and have a number of publications in the same subject. My portfolio, which showcases my past work, is available for your review. Your project piqued my interest, and I would be delighted to be part of it. Let's connect to discuss in detail. Warm regards. please check my portfolio link: https://www.freelancer.com/u/sajjadtaghvaeifr
$250 USD in 7 days
7.3
7.3

Affordable, Early Delivery. ★★★★★★★★★★★★★★I hold a Masters degree which gives me the requisite background to handle writing from various subjects. I am a highly committed person towards my work. You can rely on QualityXenter for quality and consistency in writing. We never violate copyright rules. I have vast amount of experience in this industry since I am working from 2015 as a professional writer. I provide many modifications till to get your satisfactions. I have access to enough journals to use in your research project. I always produce quality work at VERY LOW RATES so, don't worry if you have a low budget for your work, I will be very happy to make a new client like you. I am producing quality work for my clients including ARTICLE WRITING, REPORT WRITING, ESSAY WRITING, RESEARCH PAPERS, BUSINESS PLAN, TECHNICAL WRITING, MATLAB, THESIS, ACCOUNTING & FINANCE work ETC. Go through my profile link https://www.freelancer.com/u/qualityxenter
$30 USD in 1 day
6.1
6.1

Hi, I have read the project description and can support your in-silico host–virus interaction study from hypothesis development through publication-ready analysis. I have experience with transcriptomic data mining, GEO and ArrayExpress datasets, R/Bioconductor and Python workflows, differential expression analysis, cross-study meta-analysis, pathway interpretation, molecular docking, and scientific figure preparation. I will develop a biologically meaningful and testable hypothesis, curate and harmonise suitable public datasets, identify consistent host-response signatures using adjusted p-values and effect sizes, and translate the strongest findings into targeted docking experiments. You will receive reproducible scripts, cleaned datasets, statistical outputs, forest plots, high-resolution manuscript figures, docking files, documented methods, and a concise interpretation linking the transcriptomic and structural results. I can also assist with organising the findings into one or more manuscript-ready research narratives. Please message me to discuss the project in detail. Thanks, Soha
$100 USD in 3 days
6.4
6.4

Hello, My background in Python analysis workflows fits the GEO and ArrayExpress curation, harmonised expression matrices, and reproducible scripts you need. I can handle Statistical Analysis for differential expression and meta-analysis, with adjusted p-values, effect sizes, and forest plots that do not need a microscope to understand. I will connect transcriptomic host signatures to docking work, keeping AutoDock Vina and PyMOL outputs tied to the biology. Machine Learning (ML) can help rank stronger signals if it adds value, while Data Visualization will shape publication-ready figures, tables, and a short findings narrative. Best regards, Teo
$200 USD in 2 days
4.9
4.9

Hi, I will design and execute an in silico pipeline to take your host virus interaction idea to manuscript ready results. I performed a differential expression meta analysis across nine GEO respiratory virus datasets that yielded a prioritized host signature used for follow up docking. My approach will shape a testable hypothesis grounded in current literature, mine and curate GEO and ArrayExpress studies, standardize and harmonize an expression matrix in reproducible R or Python workflows, run differential expression and a robust meta analysis with adjusted p values, effect sizes and forest plots, and map top transcriptomic hits to molecular docking using AutoDock Vina and PyMOL. Deliverables will include cleaned data, scripts, statistical outputs, high resolution figures formatted for journals, docking files and a concise methods narrative. I can deliver the initial hypothesis, harmonized matrix and meta analysis figures in four weeks and the complete docking plus final package in six weeks. Do you want to prioritize a particular virus strain or host tissue for dataset selection? Ali Zain
$140 USD in 7 days
4.8
4.8

Hello, I can develop a fully reproducible in-silico workflow covering hypothesis formulation, GEO/ArrayExpress dataset selection, preprocessing and harmonisation, differential expression, cross-study meta-analysis, and molecular docking. The final package will include documented R/Python scripts, effect sizes and adjusted p-values, forest plots, publication-ready figures, docking scores and structures, and a concise results narrative suitable for manuscript development. My approach would begin with a focused literature review to define a biologically meaningful host–virus question, followed by careful study selection and batch-aware data integration. I would then identify consistent host signatures across datasets and prioritise the strongest candidates for docking against relevant viral proteins. Could you please confirm the virus or virus family you want to focus on, and whether you already have a preferred host species, tissue type, or disease stage? Regards,
$3,500 USD in 15 days
4.8
4.8

Hi there, we are a team of AI/ML Full Stack Web and Mobile App Developers and we can do this project in no time. Thanks Ashish Kumar.
$140 USD in 7 days
4.6
4.6

As a dedicated bioinformatician with strong proficiency in Python, I am well-equipped to assist you in your ambitious viral immunology investigation. My experience lies in transforming vast quantities of public data, much like the transcriptomic datasets you require, into highly meaningful and publishable biological insight. My core skills in R/Bioconductor and Python align perfectly with your project needs, ensuring I can curate, standardize, and construct a harmonized expression matrix from GEO or ArrayExpress to provide reproducible results. Not only do I specialize in differential expression analysis and robust meta-analyses, but I can also perform molecular docking experiments using tools such as AutoDock Vina and PyMOL. This means I can skillfully translate the strongest correlated signals into actionable insights that probe host and viral protein interactions. More than just providing results, I strive for user-optimized outputs that contribute directly to the scientific publication process. This means you can anticipate a concise package of cleaned data, scripts, statistical outputs, high-resolution plots, docking files aligned with a short yet comprehensive narrative of findings - professionally formatted for direct journal submission inclusion. Let me transform your intriguing idea into impactful scientific discovery through my deep understanding of your requirements and domain expertise.
$100 USD in 6 days
4.2
4.2

Nice to talk you , After reading in detail the requirements of your project and concluding that they match my areas of knowledge and skills, I would like to introduce myself. My name is Anthony Muñoz and I am the lead engineer for DS Pro IT agency. I have worked for over 10 years in Backend and software development and have successfully done multiple jobs. It will be a pleasure to work together to make your project a reality. Please feel free to contact me. I´m looking forward to working with you. I really appreciate your time and remain attentive to any request or question. Greetings
$224 USD in 7 days
3.8
3.8

Dear Client, I am a microbiologist and bioinformatics researcher with a proven track record in transcriptomics and structural modeling, ready to build your in-silico host–virus study from hypothesis to manuscript. I will mine GEO and ArrayExpress to curate and harmonize public transcriptomic datasets using R/Bioconductor (GEOquery, limma), execute robust cross-study differential expression meta-analyses with adjusted p-values and publication-grade forest plots, and translate your top host signatures directly into structural docking experiments using AutoDock Vina, PyMOL, and ChimeraX. You will receive an end-to-end, reproducible pipeline alongside publication-ready figures, tables, and a structured narrative formatted for immediate journal submission. My verifiable academic profile is available via my ORCID: 0009-0004-5088-5019 and LinkedIn Profile, and I am ready to start shaping your hypothesis immediately. Warm Regards, Nadir Zaman Bioinformatics & Computational Biology Specialist
$140 USD in 7 days
3.9
3.9

Hi, I can support your in-silico host–virus interaction study from hypothesis formulation to reproducible transcriptomic analysis, meta-analysis, docking support, and manuscript-ready outputs. My approach will start with reviewing the target virus/host context and selecting suitable GEO or ArrayExpress datasets. I’ll then clean and harmonize the expression data, run differential expression analysis, perform cross-study meta-analysis, and prioritize consistent host signatures using adjusted p-values, effect sizes, and clear plots. I’m comfortable with Python, R/Bioconductor, GEO/ArrayExpress mining, limma/DESeq2-style workflows, meta-analysis, pathway enrichment, statistical reporting, data visualization, scientific writing, AutoDock Vina, and PyMOL. Deliverables will include a testable hypothesis, curated dataset list, harmonized expression matrix, reproducible scripts, DE/meta-analysis outputs, forest plots, publication-ready figures, prioritized host signatures, docking scores/visualizations, and a short findings narrative for manuscript drafting. I’ll focus on a clean, reproducible, publication-oriented package that links transcriptomic evidence with biologically meaningful host–virus interaction insights. Best regards Ankit
$100 USD in 2 days
3.3
3.3

As an experienced AI/ML expert and Cloud Data Engineer, I am uniquely positioned to optimize your in-silico study. My proven ability to transform large-scale, complex data into actionable insights aligned with the needs of diverse sectors including finance, healthcare, and insurance means your project would benefit from a broad range of practical applications arising from my professional journey. My skillset covers AI-driven automation, intelligent workflows, as well as sophisticated analytics combining ML, Python and Statistical Analysis among others. I am confident about delivering to your specifications while staying true to your aim of finding publishable biological insights. With a focus on precision in results delivery, my work includes clean datasets, scripts, statistical outputs and high-resolution plots – all necessary for robust scientific publication. Harnessing Big public data is where I excel; from mining and curating public transcriptomic datasets using R/Bioconductor or Python workflows, performing differential expression analysis & meta-analysis across studies, to translating these findings into molecular-docking experiments with tools like Autodock Vina and PyMOL. You can be sure of comprehensive results aligning with a concise narrative that effectively communicates the meaning inherent in the data. Reach out now and let's drive those initial promising ideas all the way to publication-quality results together.
$155 USD in 3 days
2.7
2.7

Hello, I appreciate the opportunity to assist with your in-silico study on host–virus interactions. I understand your goal is to transform your initial idea into publication-ready results that will underpin scientific manuscripts. With several years of experience in bioinformatics and computational biology, I have successfully developed testable hypotheses grounded in literature and conducted comprehensive analyses of public transcriptomic datasets. I am proficient in R/Bioconductor and Python, ensuring that any code I produce is reproducible and well-documented. To achieve your project goals, I propose the following approach: - Develop a clear hypothesis based on current literature and preliminary data. - Mine and standardize transcriptomic datasets from GEO or ArrayExpress to create a harmonized expression matrix. - Conduct differential expression analysis and perform meta-analysis to identify consistent host signatures. - Utilize tools like AutoDock Vina and PyMOL for molecular docking experiments linked to the strongest transcriptomic signals. - Deliver a complete results package, including cleaned data, scripts, high-resolution plots, and formatted figures ready for publication. I am eager to start this project and confident in my ability to deliver high-quality results that meet your expectations. Please let me know when you would like to discuss this further.
$30 USD in 7 days
1.0
1.0

Hello, I can help you develop and execute this in-silico host–virus interaction study using Python-based bioinformatics workflows. I have strong experience with Python, data analysis, automation, scientific computing, and building reproducible research pipelines. I can support the complete workflow, including literature-driven hypothesis refinement, public transcriptomic dataset collection from GEO/ArrayExpress, data cleaning and harmonization, differential expression analysis, statistical evaluation, visualization, and interpretation of biological signatures. For the computational pipeline, I can build reproducible workflows using Python tools such as pandas, NumPy, SciPy, statsmodels, Scanpy (where applicable), and visualization libraries, while integrating docking workflows with tools such as AutoDock Vina and PyMOL when required. Deliverables will include documented scripts, processed datasets, statistical outputs, publication-quality figures, docking results, and a structured summary suitable for manuscript development. I focus on accurate, reproducible, and well-documented scientific computing workflows and would be happy to help turn your hypothesis into a strong computational study.
$140 USD in 2 days
0.4
0.4

Hi, I'm interested in your project and can complete it within a day using R/Bioconductor, GEOquery, limma, and AutoDock Vina. Building a manuscript-ready pipeline from GEO/ArrayExpress transcriptomics through to docking validation of host-virus protein hits is exactly the kind of work I do regularly. My approach: pull candidate host-virus datasets (likely respiratory or hepatotropic virus studies depending on your hypothesis), harmonize probe/gene annotation across platforms, batch-correct with ComBat, then run limma/DESeq2 per study followed by a random-effects meta-analysis (metafor) to get pooled effect sizes and forest plots. Top DE genes get mapped to protein structures via UniProt/PDB, then docked against viral proteins in AutoDock Vina, with PyMOL for interaction visualization. One thing worth flagging early: batch effects across GEO platforms often masquerade as biological signal, so I'll run surrogate variable analysis before finalizing the DE list to avoid false positives in the meta-analysis. Happy to share a proposed hypothesis and dataset shortlist first before committing to full analysis. Can start immediately. Best, Emrah
$118 USD in 1 day
0.0
0.0

⭐Dear client⭐ I'm Diego, a seasoned Senior Full-Stack Engineer with extensive experience in using Python for complex data analysis. I've successfully delivered end-to-end bioinformatics projects like this one several times, and my comprehensive knowledge of R/Bioconductor and Python workflows will ensure a reproducible, efficient analysis on your datasets. A published manuscript-quality result is not just about the analysis but also about the presentation. I understand your need to have results that are not only scientifically rigorous but also presented in the format suitable for immediate journal submission. My track record of providing high-resolution plots, cleaned data, statistical outputs and concise narratives will be invaluable in this regard. What sets me apart is that my skills and approach go beyond the technical aspects - while I understand how to handle large public datasets, my innate scientific curiosity enables me to formulate testable hypotheses grounded in current literature, ensuring that we generate meaningful biological insights from this project. I am exceptionally skilled in performing differential expression analyses and meta-analyses across studies, which will allow us to identify consistent host signatures effectively. Lastly, my proficiency with molecular docking experiments using tools like AutoDock Vina and PyMOL aligns perfectly with your needs. Let's collaborate on shaping a strong hypothesis and transform Looking forward to your message.
$30 USD in 6 days
0.0
0.0

I can turn the requirements of Bioinformatics Lead for Viral Immunology into a reliable Python solution—not a fragile one-time script. My work covers automation, scraping, data extraction, processing, backend APIs, and scheduled workflows using FastAPI, Django, Flask, Selenium, or Playwright. Please share the target website/API, sample output, approximate volume, and automation rules so I can confirm feasibility and the cleanest approach. Portfolio: https://www.freelancer.in/u/heenafullstacken Heena A Plus IT House
$90 USD in 7 days
0.0
0.0

Hi. I saw your project and think I can deliver what you need. I understand your details and know what needs to be done. I will keep the plan simple, ask for feedback. and focus on results. I’m offering best quality and highest performance at lowest price I have 10 years of experience in Python, Machine Learning (ML) I have completed many projects and delivered great. clear. and usable work for clients You can view my portfolio at Hello. I am available now to assist you. Warm regards, bhargav922002
$175 USD in 3 days
0.0
0.0

Hi, this project aligns with recent full-stack delivery work on React and API integrations. I have shipped similar scope with clear milestones and clean handoff. Happy to discuss details in chat.
$30 USD in 7 days
0.0
0.0

If you’d like, I can walk you through the first steps in a quick free consultation — no obligation. You’ll walk away with clarity even if you choose another freelancer. I can help you transform your initial hypothesis into publication-quality results, focusing on the intricate host–virus interactions that will support your manuscripts. I understand the importance of shaping a clear hypothesis grounded in current literature and the need for standardized datasets. Mining public transcriptomic datasets and creating a harmonized expression matrix will be my priority, ensuring reproducibility in R or Python. My approach will emphasize clear communication and dependable delivery. I will perform thorough differential expression analysis and robust meta-analysis to identify consistent host signatures, followed by molecular-docking experiments to link transcriptomic hits with protein interactions. Let's discuss how we can bring your research to fruition. Regards, Adriaan
$150 USD in 7 days
0.0
0.0

Marrakesh, Morocco
Member since Jul 20, 2026
$20-60 USD
€750-1500 EUR
$2-8 AUD / hour
₹600-1500 INR
$30-250 AUD
$200-600 USD
£10-20 GBP
₹12500-37500 INR
$30-250 USD
₹12500-37500 INR
₹12500-37500 INR
$10-30 USD
£250-750 GBP
$15-25 CAD / hour
$15-25 USD / hour
₹10000-15000 INR
$30-250 USD
$10-30 USD
₹12500-37500 INR
$750-1500 USD
₹750-1250 INR / hour